Some derivatives of quinoxaline–2,3(1H, 4H)-dione were synthesized and characterized by IR, 1H-NMR, 13C-NMR and Mass spectral studies. Compounds were evaluated for their in-vitro antibacterial and antifungal activities. It was noted that Amino substituted compounds demonstrated potent antibacterial activity with moderate antifungal activity whilst nitro derivatives showed lesser activity. Among all compounds sulphonamides derivatives exhibited potent activity against test bacterial species. SD values indicated the significant disparity in structure of the compound and activity.
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